Sunday April 19

13:00 - 17:00 Registration Open
16:00 - 16:10 Opening by Haico van Attikum

Plenary Session I: New perspectives on genome maintenance
16:10 - 16:50 Keynote speaker Johannes Walter "AI-driven mechanistic analysis of genome maintenance"
17:00 - 17:25 Simon Boulton "Replication stress tolerance in ALT cancers"

17:45 Welcome drinks
18:30 - 19:45 Dinner
20:00 - 22:00 Poster viewing session I
22:00 Jam-session

Monday April 20

Plenary Session II: Double Strand Break repair
09:00 - 09:25 Petr Cejka "Mechanisms of DNA end resection"
09:25 - 09:50 Dan Durocher "Charting genome maintenance mechanisms"
09:50 - 10:05 Selected talk
10:05 - 10:20 Selected talk

10:30 - 11:00 Coffee/tea break

Plenary Session III: Double Strand Break repair
11:00 - 11:25 Patrick Sung "Homologous recombination licensing role of the BRCA-BARD1 Tumor Suppressor Complex"
11:25 - 11:50 Xiaodong Zhang "Structures and molecular mechanism of RAD51 modulators in genome maintenance"
11:50 - 12:05 Selected talk
12:05 - 12:20 Selected talk

12:30 - 13:30 Lunch

Plenary Session IV: Transcription stress
13:45 - 14:10 Tomoo Ogi
14:10 - 14:35 Jesper Svejstrup "Balancing transcription and genome stability"
14:35 - 14:50 Selected talk

14:50 - 15:20 Coffee/tea break

Plenary Session V: Consequences of replication/transcription stress
15:30 - 15:55 Karlene Cimprich "Mechanisms for RNA-mediated genome instability"
15:55 - 16:20 Roger Greenberg "Molecular patterns that link the DNA damage and immune responses"
16:20 - 16:35 Selected talk

17:00 - 18:30 Poster discussion session I 
18:30 - 19:45 Dinner
20:00 - 22:00 Poster viewing session II 
22:00 Jam-session

Tuesday April 21

Plenary Session VI: Replication stress 
09:00 - 09:25 Kristijan Ramadan "Nucleophagy as a DNA replication–coupled repair pathway" 
09:25 - 09:50 David Cortez "Replication-coupled repair mechanisms to maintain genome stability"
09:50 - 10:05 Selected talk
10:05 - 10:20 Selected talk

10:30 - 11:00 Coffee/tea break

Plenary Session VII: DDR and Cell Cycle
11:00 - 11:25 Matthias Altmeyer "Yin and Yang of cell cycle-controlled genome maintenance"
11:25 - 11:50 Andrew Blackford "DNA damage responses during mitosis"
11:50 - 12:05 Selected talk
12:05 - 12:20 Selected talk

12:30 - 13:30 Lunch

Plenary Session VIII: Crosslink repair 
13:45 - 14:10 KJ Patel 
14:10 - 14:35 Julian Duxin "Mechanisms of TOP2cc repair"
14:35 - 14:50 Selected talk

14:50 - 15:20 Coffee/tea break

Plenary Session IX: Crosslink repair
15:30 - 15:55 Julian Stingele "Cellular responses to RNA damage"
15:55 - 16:20 Lori Passmore "Mechanisms of DNA crosslink repair"
16:20 - 16:35 Selected talk

17:00 - 18:30 Poster discussion session II 
18:30 - 19:45 Dinner
20:00 - 22:00 Poster viewing session III
22:00 Jam-session
 

Wednesday April 22

Plenary Session X: Stability and evolution of the genome
09:00 - 09:25 Andre Nussenzweig "Genome stability in mitotic & post-mitotic cells"
09:25 - 09:50 David Pellman "Molecular mechanisms driving rapid evolution of the genome"
09:50 - 10:05 Selected talk
10:05 - 10:20 Selected talk

10:30 - 11:00 Coffee/tea break

Plenary Session XI: DNA repair and nuclear organization
11:00 - 11:25 Evi Soutouglou 
11:25 - 11:50 Gaëlle Legube "Chromatin and chromosome dynamics at DSBs"
11:50 - 12:15 Nitika Taneja "Mechanisms of chromatin re-organization in response to replication stress
12:15 - 12:30 Selected talk

12:45 - 13:45 Lunch

Free afternoon and evening 
 

Thursday April 23

Plenary Session XII: End-joining repair
09:00 - 09:25 Raphael Ceccaldi "Novel insights into mitotic DNA repair by Pol Theta"  
09:25 - 09:50 Agnel Sfeir "MMEJ chronicles: from mitosis to ecDNA"
09:50 - 10:05 Selected talk
10:05 - 10:20 Selected talk

10:30 - 11:00 Coffee/tea break

Plenary Session XIII: DNA damage and mutagenesis
11:00 - 11:25 Serena Nik-Zainal "Influence of DNA damage and repair on indel and structural variation signatures"
11:25 - 11:50 Kasper Fugger "Detoxification of modified nucleotides by MTH1 safeguards genome stability"
11:50 - 12:05 Selected talk
12:05 - 12:20 Selected talk

12:30 - 13:30 Lunch

Plenary Session XIV: DNA damage signaling 
13:45 - 14:10 Shan Zha "The deletion illusion: why DNA damage response inhibitors seem to do more harm"
14:10 - 14:35 Martin Taylor"Genetic background shapes the response to DNA damage"
14:35 - 14:50 Selected talk

14:50 - 15:20 Coffee/tea break

Plenary Session XV: DNA damage signaling 
15:30 - 15:55 Niels Mailand "Histone biogenesis and genome maintenance"
15:55 - 16:20 Helle Ulrich "Regulation of DNA damage bypass by the ubiquitin system"
16:20 - 16:35 Selected talk
16:35 - 16:50 Selected talk

17:15 - 18:45 Poster discussion session III 
19:30 Conference dinner including poster prize ceremony
Adjacent  Jam-session, extended

Friday April 24

Plenary Session XVI: Genome instability and disease 
09:00 - 09:25 Ross Chapman "Beyond HR: a new function for BRCA1 in tumour suppression"
09:25 - 09:50 Steve Jackson "Cellular responses to DNA damaging anti-cancer agents: mechanistic insights and clinical implications"
09:50 - 10:05 Selected talk
10:05 - 10:20 Selected talk

10:30 - 11:00 Coffee/tea break

Plenary Session XVII: Genome instability and disease
11:00 - 11:25 Chris Lord "Understanding synthetic lethality in the DDR"
11:25 - 11:50 Björn Schumacher "Genome stability in aging and disease: new perspectives from C. elegans"
11:50 - 12:35 Keynote speaker Wei Yang: "The choreographed movement of protein and DNA in nucleotide excision repair"
12:35 - 12:45 Closure meeting by Haico van Attikum

12:45 - 13:45 Lunch and departure

12:45 - 14:30 Busses to airport