Sunday April 19
Free shuttle buses will be available, running from Amsterdam Airport (Schiphol) on Sunday 19 April at:

10.30 AM, 1 PM, 2.30 PM, 3 PM, 3.30 PM and 4.30 PM. 

A contact person can be found at the meeting point in the central hall. The meeting point is a structure in the Schiphol Plaza (main hall) painted with red and white squares. It is easy to find through the signs ‘Meeting point’. The drive to the congress center Zuiderduin takes approximately 40 minutes.

Sunday April 19

13:00 - 17:00 Registration Open
16:00 - 16:10 Opening by Haico van Attikum

Plenary Session I: New perspectives on genome maintenance
16:10 - 16:50 Keynote speaker Johannes Walter "AI-driven mechanistic analysis of genome maintenance"
17:00 - 17:25 Simon Boulton "Replication stress tolerance in ALT cancers"

17:45 Welcome drinks
18:30 - 19:45 Dinner
20:00 - 22:00 Poster viewing session I 
22:00 Jam-session

Monday April 20

Plenary Session II: Double Strand Break repair
09:00 - 09:25 Petr Cejka "Mechanism of KU removal from DNA ends in DNA end resection"
09:25 - 09:50 Andre Nussenzweig "Genome stability in mitotic & post-mitotic cells"
09:50 - 10:05 Philipp Oberdoerffer "G quadruplex DNA facilitates a pervasive path to homologous recombination"
10:05 - 10:20 Kara Bernstein "High-throughput Mapping of 6,888 RAD51D variants identifies distinct biochemical functions needed for             homologous recombination"

10:30 - 11:00 Coffee/tea break

Plenary Session III: Double Strand Break repair
11:00 - 11:25 Patrick Sung "Homologous recombination licensing role of the BRCA-BARD1 Tumor Suppressor Complex"
11:25 - 11:50 Xiaodong Zhang "Structures and molecular mechanism of RAD51 modulators in genome maintenance"
11:50 - 12:05 Lauren de Haan "Tetramerization of CIP2A via its C-terminus is essential for mitotic DNA repair"
12:05 - 12:20  Arnab Ray Chaudhuri "Disrupting replication fork remodeling by loss of RAD51 paralog SWSAP1 confers therapeutic vulnerability in BRCA2 deficient cells" 

12:30 - 13:30 Lunch

Plenary Session IV: Transcription stress
13:45 - 14:10 Tomoo Ogi "Molecular Pathogenesis and Animal Models of Transcription Coupled Repair Disorders"
14:10 - 14:35 Jesper Svejstrup "Balancing transcription and genome stability"
14:35 - 14:50 Janne van Schie "The elongation factor LEO1 initiates transcription-coupled DNA repair"

14:50 - 15:20 Coffee/tea break

Plenary Session V: Consequences of replication/transcription stress
15:30 - 15:55 Karlene Cimprich "Mechanisms for RNA-mediated genome instability"
15:55 - 16:20 Helle Ulrich "Regulation of DNA damage bypass by the ubiquitin system"
16:20 - 16:35 Natàlia de Martín Garrido "Visualisation of stepwise derepression of TFIIH in global-genome nucleotide excision repair"

17:00 - 18:30 Poster discussion session I 
18:30 - 19:45 Dinner
20:00 - 22:00 Poster viewing session II 
22:00 Jam-session

Tuesday April 21

Plenary Session VI: Consequences of replication/transcription stress 
09:00 - 09:25 Kristijan Ramadan "Nucleophagy as a DNA replication–coupled repair pathway" 
09:25 - 09:50 David Cortez "Replication-coupled repair mechanisms to maintain genome stability"
09:50 - 10:05 Kumar Somyajit "Built-In Limits of Human Genome Duplication"
10:05 - 10:20 Cindy Blom "Integrator complex removes lesion-stalled RNA polymerase II after transcription-coupled repair to facilitate transcription restart"

10:30 - 11:00 Coffee/tea break

Plenary Session VII: DDR and Cell Cycle
11:00 - 11:25 Matthias Altmeyer "Yin and Yang of cell cycle-controlled genome maintenance"
11:25 - 11:50 Andrew Blackford "DNA damage responses during mitosis"
11:50 - 12:05 Jo Morris "SUMOylation controls double-strand break repair in mitosis"
12:05 - 12:20 Magdalena Rother "Exoribonuclease 1 (ERI1) ensures DNA replication by maintaining balanced histone pools"

12:30 - 13:30 Lunch

Plenary Session VIII: Excision and Crosslink repair 
13:45 - 14:10 KJ Patel "Persistent and transferable formaldehyde base adduction can propagate DNA crosslinks"
14:10 - 14:35 Julian Duxin "Mechanisms of TOP2cc repair"
14:35 - 14:50 Koichi Sato "Mechanistic insight into BRCA2 activation for RAD51 recombinase assembly"

14:50 - 15:20 Coffee/tea break

Plenary Session IX: Excision and Crosslink repair
15:30 - 15:55 Julian Stingele "Cellular responses to RNA damage"
15:55 - 16:20 Lori Passmore "Mechanisms of DNA crosslink repair"
16:20 - 16:35 Stefania Di Ciccio "Molecular mechanisms involved in the generation of COSMIC signature 17"

17:00 - 18:30 Poster discussion session II 
18:30 - 19:45 Dinner
20:00 - 22:00 Poster viewing session III
22:00 Jam-session
 

Wednesday April 22

Plenary Session X: Stability and evolution of the Genome
09:00 - 09:25 Dan Durocher "Charting genome maintenance mechanisms"
09:25 - 09:50 David Pellman "Molecular mechanisms driving rapid evolution of the genome"
09:50 - 10:05 Karen Lane "Functional profiling of SWI/SNF complexes through base editing screens identifies a role in maintaining fitness and genome stability through G quadruplex binding"
10:05 - 10:20 Román González-Prieto "RNF25 Ubiquitin E3 activity safeguards genome integrity by coordinating DNA replication, transcription and translation"

10:30 - 11:00 Coffee/tea break

Plenary Session XI: DNA repair and nuclear organization
11:00 - 11:25 Evi Soutoglou "DNA damage at Lamina Associated Domains triggers nuclear envelope reorganization and chromatin detachment to prevent  genome stability"
11:25 - 11:50 Gaëlle Legube "Chromatin and chromosome dynamics at DSBs"
11:50 - 12:15 Nitika Taneja "Mechanisms of chromatin re-organization in response to replication stress
12:15 - 12:30 Federico Teloni "Cohesin guides homology search during DNA repair using loops and sister chromatid linkages"

12:45 - 13:45 Lunch

13:45 - 15:30 DNA Curtains Flow Cell Demo by 1NA

Free afternoon and evening 
 

Thursday April 23

Plenary Session XII: End-joining repair
09:00 - 09:25 Raphael Ceccaldi "Novel insights into mitotic DNA repair by Pol Theta"  
09:25 - 09:50 Agnel Sfeir "MMEJ chronicles: from mitosis to ecDNA"
09:50 - 10:05 Joost Schimmel "Life without Polymerase Theta - Inborn loss of POLQ reveals that Theta-Mediated End Joining is dispensable for human health"
10:05 - 10:20 Priyanka Verma "HMCES prevents Pol-theta activity and promotes PrimPol-dependent repriming for error-free re-start of forks stalled by abasic sites"

10:30 - 11:00 Coffee/tea break

Plenary Session XIII: DNA damage and mutagenesis
11:00 - 11:25 Serena Nik-Zainal "Influence of DNA damage and repair on indel and structural variation signatures"
11:25 - 11:50 Kasper Fugger "Detoxification of modified nucleotides by MTH1 safeguards genome stability"
11:50 - 12:05 Percy Tumbale "Molecular basis for RNA discrimination by human DNA ligase 1"
12:05 - 12:20 Martin Reijns "Human EXO1 facilitates APE2-mediated processing of TOP1-induced DNA lesions at genome-embedded ribonucleotides"

12:30 - 13:30 Lunch

Plenary Session XIV: DNA damage signaling 
13:45 - 14:10 Shan Zha "Ku in primates - at the Crossroads of DNA Repair and RNA Biology"
14:10 - 14:35 Martin Taylor "Genetic background shapes the response to DNA damage"
14:35 - 14:50 Stephanie Panier "A new role for SLX4IP in controlling replication stress and fork stability"

14:50 - 15:20 Coffee/tea break

Plenary Session XV: DNA damage signaling 
15:30 - 15:55 Niels Mailand "Histone biogenesis and genome maintenance"
15:55 - 16:20 Björn Schumacher "Genome stability in aging and disease: new perspectives from C. elegans"
16:20 - 16:35 Bennett Van Houten "Watching base excision repair at the single molecule level: binding kinetics of PARP1 and LIG3a-XRCC1 engaging DNA nicks and chromatin"
16:35 - 16:50 Ruben van der Lugt "Genome-wide genetic screen identifies a new RUVBL1/2–PIKK regulatory axis in ATM-mediated DNA damage signaling"

17:15 - 18:45 Poster discussion session III 
19:30 Conference dinner including poster prize ceremony
Adjacent  Jam-session, extended

Friday April 24

Plenary Session XVI: Genome instability and disease 
09:00 - 09:25 Claus Storgaard Sørensen "Decoding genome stability pathways by quantitative allele and phosphosite editing"
09:25 - 09:50 Steve Jackson "Cellular responses to DNA damaging anti-cancer agents: mechanistic insights and clinical implications"
09:50 - 10:05 Alessandro Vindigni "A p53-mediated molecular switch prevents gap formation, unveiling a new PARP inhibitor sensitivity mechanism in HR-proficient cancers"
10:05 - 10:20 Mats Ljungman "Targeting DNA repair “scars” in the cancer genome using CRISPR"

10:30 - 11:00 Coffee/tea break

Plenary Session XVII: Genome instability and disease
11:00 - 11:25 Chris Lord "Understanding synthetic lethality in the DDR"
11:25 - 11:50 Ross Chapman "Beyond HR: a new function for BRCA1 in tumour suppression"
11:50 - 12:35 Keynote speaker Wei Yang: "The choreographed movement of protein and DNA in nucleotide excision repair"
12:35 - 12:45 Closure meeting by Haico van Attikum

12:45 - 13:45 Lunch and departure

12:45 - 14:30 Busses to airport